⚠️ SPOILER WARNING: Full spoilers for The Boys Season 5, Episode 5 — “One-Shots.”

Five years after the Supernatural finale aired, the fandom got something nobody dared to fully hope for: Jensen Ackles, Jared Padalecki, and Misha Collins — all three of them — back on screen together. Not at a convention. Not in a behind-the-scenes photo. On screen, in costume, in one of the wildest sequences The Boys has ever staged.

And then, in true The Boys fashion, it absolutely destroyed us.

Here’s everything that happened in the Supernatural reunion scene — and every Easter egg the writers hid inside it.

The Scene: What Actually Goes Down in “One-Shots”

The setup is classic The Boys chaos. Homelander (Antony Starr) and Soldier Boy (Jensen Ackles) are hunting for V-1, a super-compound that would make Homelander immortal and immune to Butcher’s (Karl Urban) virus threatening to wipe out all Supes. Their search takes them to Hollywood, specifically, to the lavish home of Mr. Marathon (Jared Padalecki), a former member of The Seven who was unceremoniously replaced by A-Train way back when.

Turns out Mr. Marathon is hosting a poker night. Around the table: Malchemical (Misha Collins), and a roster of real-world celebrity cameos playing fictionalized versions of themselves: Seth Rogen, Kumail Nanjiani, Will Forte, and Christopher Mintz-Plasse.

Soldier Boy and Homelander crash the party looking for information. Mr. Marathon tells them that a Supe named Bombsight (Mason Dye) has the V-1 injectable and offers to make the call. Things escalate. The celebrities start getting picked off one by one as Mr. Marathon runs through them — a grim callback to the show’s pilot, when A-Train ran through Robin. And then it all ends in tragedy: Soldier Boy snaps Malchemical’s neck, and Homelander stomps on Mr. Marathon’s head in a moment so sudden it qualifies as a genuine jumpscare.

The Winchester reunion is over before it ever really began.

The Supernatural Easter Eggs

1. “So, get this…”

The most direct nod to Supernatural comes early in the scene. When Mr. Marathon starts telling Soldier Boy a story, he leads with: “So, get this.” It’s one of Sam Winchester’s most iconic lines. The phrase he used dozens of times across 15 seasons to kick off an exposition dump for Dean. Padalecki delivering it as a different character, to a different character played by Ackles, is peak meta energy.

2. Malchemical Is Misha Collins — Which Is Already an Easter Egg

The casting of Collins as Malchemical is itself a wink at the audience. His character Castiel in Supernatural was an angel with supernatural powers who could alter reality and had a deeply complicated relationship with Dean Winchester. Malchemical is a reality-warping Supe. The parallel is not subtle, and it’s completely intentional.

3. Mr. Marathon: Vampire Hunter

On the walls of Mr. Marathon’s home, sharp-eyed viewers will spot a poster for a movie called “Mr. Marathon: Vampire Hunter.” This is a direct nod to Supernatural, where Sam and Dean Winchester spent 15 seasons hunting supernatural creatures like vampires. It’s a beautiful piece of in-world worldbuilding: the show is suggesting that Mr. Marathon leaned into his Supernatural association to build a movie career.

4. Eric Kripke Created Both Shows

The reunion isn’t just fan service. It’s a homecoming. Supernatural was created by Eric Kripke, who also created The Boys. The fact that all three leads of his original series are now appearing in his current one is a deliberate, loving full-circle moment. Kripke has been sprinkling Supernatural references and cameos throughout The Boys and its spinoff Gen V for years. This is the culmination of all of it.

5. Different Characters, Same Chemistry

Jensen Ackles addressed the surreal experience of working with his former castmates in a completely new context. As he told Deadline, the adjustment was real — new costumes, new crew, new characters — but the moment cameras cut, “it was right back to the old banter.” That natural, decades-deep chemistry bleeds through the screen, even when Ackles is in a World War II-era super-soldier suit and Padalecki is playing a washed-up Hollywood Supe. Fans who watched 15 years of Dean and Sam will feel it immediately.

6. Playing Different Versions of Each Other — Again

Ackles noted to Deadline that this wasn’t entirely new territory: “Jared and I, and Misha, we played different versions of ourselves on Supernatural for 15 years. Maybe I’d be possessed by a demon or an angel, or Jared wouldn’t have a soul, or he was playing Lucifer.” The Boys reunion is, in a strange way, just another iteration of something they’ve always done together — inhabit unexpected versions of themselves opposite each other.

7. The “Washed-Up Supes” Line

When Homelander surveys Mr. Marathon’s movie posters — all produced by Sony Pictures TV rather than Vought — he delivers a cutting line: this is where “washed-up Supes go to die.” It’s a meta joke about superhero IP and the actors who play them, but for Supernatural fans, it carries an extra sting. These are characters (and in a sense, actors) being framed as past their prime, coasting on legacy. The show is aware of exactly what it’s doing.

The Bigger Picture

What makes this scene land as more than just fan service is how committed the show is to treating it with The Boys‘ signature brutality. Collins told People that he knew fans would be “horrified” by the outcome — and he wasn’t wrong. Watching Soldier Boy kill Malchemical, and Homelander crush Mr. Marathon, is genuinely disturbing. Not because the characters are beloved (they barely had time to be), but because Ackles kills Collins and Padalecki dies on screen — and your brain can’t fully separate the actors from the moment.

That’s the cruel genius of the scene. It gives fans the reunion they wanted and then uses it against them, which is about the most The Boys thing imaginable.

For a show in its final season, it’s a bold, emotional swing and for Supernatural fans who have waited five years to see these three in the same room again, it’s a gut punch wrapped in a gift.

We wouldn’t have it any other way.

Did you catch any other Easter eggs in “One-Shots”? Drop them in the comments below.